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1

Development of First Lead Structures for Phosphoinositide 3-Kinase-C2γ Inhibitors

Freitag, Anne, Prajwal, Prajwal, Shymanets, Aliaksei, Harteneck, Christian, Nürnberg, Bernd, Schächtele, Christoph, Kubbutat, Michael, Totzke, Frank, Laufer, Stefan A.

Journal:

Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 1.49 MB

english, 2015

2

The hinge region of the scaffolding protein of cell contacts, zonula occludens protein 1, regulates interacting with various signaling proteins

Manjot Singh Bal, Victor Castro, Jörg Piontek, Christine Rueckert, Juliane K. Walter, Aliaksei Shymanets, Barbara Kurig, Hannelore Haase, Bernd Nürnberg, Ingolf E. Blasig

Journal:

Journal of Cellular Biochemistry

Year:

2012

Language:

english

File:

PDF, 1.19 MB

english, 2012

3

p87 and p101 Subunits Are Distinct Regulators Determining Class IB Phosphoinositide 3-Kinase (PI3K) Specificity

Shymanets, A., Prajwal,, Bucher, K., Beer-Hammer, S., Harteneck, C., Nurnberg, B.

Journal:

Journal of Biological Chemistry

Year:

2013

Language:

english

File:

PDF, 1.93 MB

english, 2013

4

Ras is an indispensable coregulator of the class IB phosphoinositide 3-kinase p87/p110

Kurig, B., Shymanets, A., Bohnacker, T., Prajwal,, Brock, C., Ahmadian, M. R., Schaefer, M., Gohla, A., Harteneck, C., Wymann, M. P., Jeanclos, E., Nurnberg, B.

Journal:

Proceedings of the National Academy of Sciences

Year:

2009

Language:

english

File:

PDF, 2.19 MB

english, 2009

5

Molecular determinants of PI3K -mediated activation downstream of G-protein-coupled receptors (GPCRs)

Vadas, O., Dbouk, H. A., Shymanets, A., Perisic, O., Burke, J. E., Abi Saab, W. F., Khalil, B. D., Harteneck, C., Bresnick, A. R., Nurnberg, B., Backer, J. M., Williams, R. L.

Journal:

Proceedings of the National Academy of Sciences

Year:

2013

Language:

english

File:

PDF, 1.23 MB

english, 2013

6

G Protein-Coupled Receptor-Mediated Activation of p110 by G Is Required for Cellular Transformation and Invasiveness

Dbouk, H. A., Vadas, O., Shymanets, A., Burke, J. E., Salamon, R. S., Khalil, B. D., Barrett, M. O., Waldo, G. L., Surve, C., Hsueh, C., Perisic, O., Harteneck, C., Shepherd, P. R., Harden, T. K., Smr

Journal:

Science Signaling

Year:

2012

Language:

english

File:

PDF, 2.20 MB

english, 2012

7

p21-activated Kinases (PAKs) Mediate the Phosphorylation of PREX2 Protein to Initiate Feedback Inhibition of Rac1 GTPase

Barrows, Douglas, Schoenfeld, Sarah M., Hodakoski, Cindy, Silkov, Antonina, Honig, Barry, Couvillon, Anthony, Shymanets, Aliaksei, Nürnberg, Bernd, Asara, John M., Parsons, Ramon

Journal:

Journal of Biological Chemistry

Year:

2015

Language:

english

File:

PDF, 3.32 MB

english, 2015

8

Gβγ-Copurified Lipid Kinase Impurity from Sf9 Cells

Shymanets, Aliaksei, Ahmadian, Mohammad, Nurnberg, Bernd

Journal:

Protein & Peptide Letters

Year:

2009

Language:

english

File:

PDF, 147 KB

english, 2009

9

Metabolic disorders in men with suspected prostate cancer

Shymanets, S.V., Danilova, L.I., Karman, A.V., Lushchyk, M.L., Gapeenko, E.V.

Journal:

European Urology Supplements

Year:

2016

Language:

english

File:

PDF, 278 KB

english, 2016

10

Better understanding of phosphoinositide 3-kinase (PI3K) pathways in vasculature: Towards precision therapy targeting angiogenesis and tumor blood supply

Tsvetkov, D., Shymanets, A., Huang, Yu, Bucher, K., Piekorz, R., Hirsch, E., Beer-Hammer, S., Harteneck, C., Gollasch, M., Nürnberg, B.

Journal:

Biochemistry (Moscow)

Year:

2016

Language:

english

File:

PDF, 599 KB

english, 2016

11

The p101 subunit of PI3Kγ restores activation by Gβ mutants deficient in stimulating p110γ

Shymanets, Aliaksei, Ahmadian, Mohammad R., Kössmeier, Katja T., Wetzker, Reinhard, Harteneck, Christian, Nürnberg, Bernd

Journal:

Biochemical Journal

Year:

2012

Language:

english

File:

PDF, 642 KB

english, 2012

12

Different inhibition of Gβγ-stimulated class IB phosphoinositide 3-kinase (PI3K) variants by a monoclonal antibody. Specific function of p101 as a Gβγ-dependent regulator of PI3Kγ enzymatic activity

Shymanets, Aliaksei, Prajwal,, Vadas, Oscar, Czupalla, Cornelia, LoPiccolo, Jaclyn, Brenowitz, Michael, Ghigo, Alessandra, Hirsch, Emilio, Krause, Eberhard, Wetzker, Reinhard, Williams, Roger L., Har

Journal:

Biochemical Journal

Year:

2015

Language:

english

File:

PDF, 1.58 MB

english, 2015

13

Targeted second repeat biopsy for atypical small acinar proliferation after first set of systematic prostate rebiopsy

Karman, A., Shymanets, S., Rolevich, A., Minich, A., Krasny, S.

Journal:

European Urology Supplements

Year:

2016

Language:

english

File:

PDF, 277 KB

english, 2016

14

Nanodiscs for INPHARMA NMR Characterization of GPCRs: Ligand Binding to the Human A2A Adenosine Receptor

Fredriksson, Kai, Lottmann, Philip, Hinz, Sonja, Onila, Iounut, Shymanets, Aliaksei, Harteneck, Christian, Müller, Christa E., Griesinger, Christian, Exner, Thomas E.

Journal:

Angewandte Chemie International Edition

Year:

2017

Language:

english

File:

PDF, 1.69 MB

english, 2017

15

Nanodiscs for INPHARMA NMR Characterization of GPCRs: Ligand Binding to the Human A2A Adenosine Receptor

Fredriksson, Kai, Lottmann, Philip, Hinz, Sonja, Onila, Iounut, Shymanets, Aliaksei, Harteneck, Christian, Müller, Christa E., Griesinger, Christian, Exner, Thomas E.

Journal:

Angewandte Chemie

Year:

2017

Language:

english

File:

PDF, 1.62 MB

english, 2017

16

Diagnostic accuracy of transrectal ultrasound and multiparametric MRI after primary negative prostate biopsy

Karman, A., Shymanets, S., Kharuzhyk, S., Minich, A., Rolevich, A., Krasny, S.

Journal:

European Urology Supplements

Year:

2017

Language:

english

File:

PDF, 214 KB

english, 2017

17

Rac1-Stimulated Macropinocytosis Enhances Gβϒ Activation of PI3Kβ

Erami, Zahra, Khalil, Bassem D, Salloum, Gilbert, Yao, Yanhua, LoPiccolo, Jaclyn, Shymanets, Aliaksei, Nürnberg, Bernd, Bresnick, Anne R., Backer, Jonathan M.

Journal:

Biochemical Journal

Year:

2017

Language:

english

File:

PDF, 10.53 MB

english, 2017

18

Salmonella Typhimurium effector SseI inhibits chemotaxis and increases host cell survival by deamidation of heterotrimeric Gi proteins

Brink, Thorsten, Leiss, Veronika, Siegert, Peter, Jehle, Doris, Ebner, Julia K., Schwan, Carsten, Shymanets, Aliaksei, Wiese, Sebastian, Nürnberg, Bernd, Hensel, Michael, Aktories, Klaus, Orth, Joachi

Journal:

Year:

2018

Language:

english

File:

PDF, 16.36 MB

english, 2018